Chronic Stress, Cognition, and Food Cue Reactivity in Prader-Willi Syndrome: A Magnetoencephalography Study

The Hospital for Sick Children, Endocrinology, Neurosciences & Mental Health

The goal of this project is to see how areas of the brain involved in hunger, stress, emotion, and learning are related to changes in body hormones. We will be comparing results between children/adolescents with and without Prader-Willi Syndrome (PWS). All data and sample collection will occur during two separate study visits to SickKids. Study measures include fasting bloodwork, simple physical measurements, a hair sample, a magnetoencephalography (MEG) session, and a full neuropsychological assessment. Compensation for parking, travel, and time is provided. Volunteer hours are offered.

Eligibility Criteria

All genders

7 to 16 years old

Inclusion Criteria: Children and adolescents aged 7-16 years with or without a diagnosis of PWS

Exclusion Criteria: History of major head trauma; Diagnosis of diabetes; Current or recent smoker (i.e. >2 cigarettes/week during past year); Metal in body (braces, permanent retainer, shrapnel, metal slivers, unremovable metal adornments); Use of certain medications

Study Tasks

Physical measurements
Fasting blood work
Hair sample
Non-invasive magnetoencephalography (MEG) brain scan
Neuropsychological assessment


This study has been approved by the SickKids Research Ethics Board (REB#1000061983)



Activity and Time

Food and Drink, Psychology, Health and Wellness

Observational Study


2 hour(s) - 5 hour(s) per session

2 session(s)


Gift card & Volunteer hours


Transportation or Parking

Study Address

555 University Ave Toronto, Ontario, Canada, M5G 1X8

Posting date: Jul 7, 2020